Product Benefits

Onboard cameras provide visual images during freezing

Enabling the easier selection of only good grids based on visual images during freezing reduces the requirement for costly microscope screening and saves valuable research time.

High-speed plunging

chameleon’s high speed plunging capability reduces air-water interface protein denaturation effects and allows better handling of difficult samples to improve quality and enable better research outcomes.

Blot-free technology

The blot-free technology using self wicking grids minimizes variability and enables researchers to gain precise sample specific control of ice thickness.

Precise automated grid handling

With almost no manual handling required, chameleon eliminates common grid damage and loss issues to increase workflow efficiency and reduce waste.

Guided workflows enable simple set up, use and cleaning

Intuitive design makes the instrument easy to use even for novice operators, minimizing training time and streamlining set up.

In-line glow discharge

Easily apply real time adjustments to perfect your sample behaviour and achieve the perfect ice thickness.

Automated cryogen level sensing and temperature control

Ensure the safe storage and control of cryogens in an automated drawer to maintain their stability and quality and assure research integrity.

Captures all relevant grid parameters and images

Improved data collection and record keeping enables future repeatability as well as data mining to inform new research avenues.

Technical Specification

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The chameleon has enabled an efficient cryoEM workflow for Arvinas by allowing us to freeze our samples promptly upon elution from the column, thus allowing rapid capture of complexes on grids ready for cryoEM data collection. By improving sample quality and reducing screening loads on microscopes, chameleon has allowed us to leverage both academic and industry partners for data collection. This allows us to focus our resources and efforts on producing high-quality protein complexes to advance the field of PROTAC® protein degradation.

Katie Digianantonio, PhD

Research Investigator

For more information or ordering the products, please email us at cs@medikonia.com.