Product Overview

REGM™ Renal Epithelial Cell Growth Medium is formulated to maintain and expand most renal epithelial cells. REGM™ contains 0.5% serum.    

Select References: 

• Diabetic Nephropathy is a chronic, progressive renal disease/diabetic kidney disease that develops in approximately one third of people with diabetes.  In a study, Lonza’s human proximal tubular epithelial cells were cultured in respective media (REGM™). The group investigated the role of KLK1 (kallikrein) in tubular pro-inflammatory responses in cultured human RPTEC and examined the role of PAR-4 (Protease-Activated Receptor 4) activation in KLK1-mediated signaling in the development of DN. Yiu WH, Wong DW, Chan LY, Leung JC, Chan KW, Lan HY, Lai KN, Tang SC. Tissue Kallikrein Mediates Pro-Inflammatory Pathways and Activation of Protease-Activated Receptor-4 in Proximal Tubular Epithelial Cells. PLoS ONE (2014); 9(2): e88894

• Renal Graft Research: In vitro renal epithelial cell culture models have provided a great deal of information about the outcome of renal clinical transplantation models. In a study carried out using Lonza’s Primary Human Renal Proximal Tubular Epithelial cells maintained in REGM™ renal epithelial growth media (cat# CC-2553 & CC-3190 respectively), the group study the effects of HCMV (Human cytomegalovirus) infection on renal cells. Masako Shimamura, Joanne E. Murphy-Ullrich and William J. Britt. Human Cytomegalovirus Induces TGF-β1 Activation in Renal Tubular Epithelial Cells after Epithelial-to-Mesenchymal Transition. PLoS Pathogens. (2010); 6(11): e1001170

Content

1 x REBM™ Basal Medium (CC-3191), 500 mL

1 x REGM™ Singlequots™ Supplement Pack (CC-4127) containing:

1 x Green Cap Vial with hEGF, 0.50 mL
1 x Lilac Cap Vial with Insulin, 0.50 mL
1 x Natural Cap Vial with Hydrocortisone, 0.50 mL
1 x Red Cap Vial with GA-1000, 0.50 mL
1 x Bottle FBS, 2.50 mL
1 x Natural Cap Vial with Transferrin, 0.50 mL
1 x Amber Vial with Triiodothyronine, 0.50 mL
1 x Amber Vial with Epinephrine, 0.50 mL

Catalog #: CC-3190

Please email us at cs@medikonia.com for any enquiry. To place an order, please include the catalog number(s) of the product(s) in the email.

Instructions for culturing Clonetics™ Human Renal Cells

Reference guidefor human and animal cells from normal to diseased, fresh and cryopreserved