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Biological Description

Description: Nafamostat mesylate, a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.

Chemical Properties

Molecular Weight: 539.58

Formula: C21H25N5O8S2

CAS No.: 82956-11-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 54 mg/mL (100 mM)

H2O: 54 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Catalog #: T2392

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References and Literature

1. Sundaram S, et al. Thromb Haemost, 1996, 75(1), 76-82.

2. Uchiba M, et al. Thromb Res, 1994, 74(2), 155-161.

3. Ugawa S, et al. Biochem Biophys Res Commun, 2007, 363(1), 203-208.

4. Ui H, et al. Eur J Pharmacol, 2006, 530(1-2), 172-178.

5. Uwagawa T, et al. Anticancer Res, 2009, 29(8), 3173-3178.

6. Homma S, et al. Nafamostat mesilate, a serine protease inhibitor, suppresses interferon-gamma-induced up-regulation of programmed cell death ligand 1 in human cancer cells. Int Immunopharmacol. 2018 Jan;54:39-45.