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Biological Description

Description: Lopinavir is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding to serum proteins than the structurally-related drug ritonavir.

Targets&IC50: HIV protease:1.3 pM(Ki)

Chemical Properties

Molecular Weight: 628.8

Formula: C37H48N4O5

CAS No.: 192725-17-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 116 mg/mL (184.5 mM)

DMSO: 116 mg/mL (184.5 mM)

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Catalog #: T1623

Please email us at cs@medikonia.com for any enquiry. To place an order, please include the catalog number(s) of the product(s) in the email.

References and Literature

1. Sham HL, et al. Antimicrob Agents Chemother, 1998, 42(12), 3218-3224.

2. Kumar GN, et al. Drug Metab Dispos, 1999, 27(1), 86-91.

3. Vishnuvardhan D, et al. AIDS, 2003, 17(7), 1092-1094.

4. Gonzalez LM, et al. Antimicrob Agents Chemother, 2003, 47(9), 2817-2822.

5. Weemhoff JL, et al. J Pharm Pharmacol, 2003, 55(3), 381-386.

6. Chu, Liuxi, et al. Simultaneous quantitation of zidovudine, efavirenz, lopinavir and ritonavir in human hair by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry [J]. Journal of Chromatography B . 2018 Oct 15;1097-1098:54-63.

7. Fical L, Khalikova M, Kočová Vlčková H, et al. Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes[J]. Molecules. 2021, 26(8): 2123.