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Biological Description

Description: Ritonavir is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other HIV proteases by blocking their degradation by cytochrome P450.

Chemical Properties

Molecular Weight: 720.95

Formula: C37H48N6O5S2

CAS No.: 155213-67-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 14.4 mg/mL (20 mM)), with gentle warming

Ethanol: 7.2 mg/mL (10 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Catalog #: T1525

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References and Literature

1. Eagling VA, et al. Br J Clin Pharmacol, 1997, 44(2), 190-194.

2. Kumar GN, et al. J Pharmacol Exp Ther, 1996, 277(1), 423-431.

3. Weichold FF, et al. J Hum Virol, 1999, 2(5), 261-269.

4. Drewe J, et al. Biochem Pharmacol, 1999, 57(10), 1147-1152.

5. Kumar GN, et al. Drug Metab Dispos, 1999, 27(8), 902-908.

6. Fical L. Vývoj UHPLC-MS/MS metody pro analýzu vybraných antivirotik v HILIC a RP módu[J]. 2020

7. Chu, Liuxi, et al. Simultaneous quantitation of zidovudine, efavirenz, lopinavir and ritonavir in human hair by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry [J]. Journal of Chromatography B . 2018 Oct 15;1097-1098:54-63.

8. Fical L, Khalikova M, Kočová Vlčková H, et al. Determination of Antiviral Drugs and Their Metabolites Using Micro-Solid Phase Extraction and UHPLC-MS/MS in Reversed-Phase and Hydrophilic Interaction Chromatography Modes[J]. Molecules. 2021, 26(8): 2123.