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Biological Description

Description: Quercetin, a natural flavonoid present in vegetables, fruit, and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor.

Targets&IC50: PI3Kγ:2.4 μM, PI3Kδ:3.0 μM

Chemical Properties

Molecular Weight: 302.238

Formula: C15H10O7

CAS No.: 117-39-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

Ethanol: 4 mg/mL(13.2 mM)

DMSO: 57 mg/mL (188.6 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Catalog #: T2174

Please email us at cs@medikonia.com for any enquiry. To place an order, please include the catalog number(s) of the product(s) in the email.

References and Literature

1. Navarro-Nunez L, et al. Fitoterapia, 2010, 81(2):75-80.

2. Yu XB, et al. Yao Xue Xue Bao, 1996, 31(3), 176-181.

3. Yang F, et al. PLoS One. 2015, 10(5), e20128277.

4. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet[J]. Planta medica. 2019.

5. Li Zhu, Ruonan Liu, Tangrong Liu, Xuan Zou, Zhe Xu, Huashi Guan. A novel strategy to screen inhibitors of multiple aminoglycoside-modifying enzymes with ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry[J]. Journal of Pharmaceutical and Biomedical Analysis. 2019 Feb 5;164:520-527.

6. Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin[J]. Biochemical and Biophysical Research Communications. 2020

7. Shim K S, Hwang Y H, Jang S A, et al. Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation[J]. Molecules. 2021, 26(4): 784.

8. Peng D, Chen L, Sun Y, et al. Melanoma suppression by quercein is correlated with RIG-I and type I interferon signaling[J]. Biomedicine & pharmacotherapy= Biomedecine & pharmacotherapie. 2020, 125: 109984.

9. Shim K S, Hwang Y H, Jang S A, et al. . Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice[J]. Nutrients.  2020, 12(7): 1927.