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Berthold HERM LB 500 with fLumo detector

The HERM is a dedicated radio HPLC monitor which can be connected to different detectors. Providing flexibility, reproducibility and sensitivity, the HERM offers a safe and user-friendly solution for quality control laboratories. The HERM with fLumo Chemiluminescence detector for HPLC systems uses a highly sensitive head-on photon counting detector with low background which is perfect for PET quality control, among other applications. Different measuring cells can be used to adapt for flow rates, activities and isotopes. For gamma and high energy beta isotopes, the HERM with NaI detector is available.

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Highlights

 

Simple integration into every HPLC system

 

The HERM makes integration into your existing HPLC system easy. The PC connection can be established instantly via the USB port. By using the analog 0-1 V output, the HERM can be integrated into every HPLC system. In addition, its compact design makes it easy to fit in a hot cell.

 

Highly sensitive luminescence monitoring

 

In the fLumo detector the low noise head-on PMT has been designed to face the sample coil directly. The result is a high sensitivity detector for even the faintest traces of chemiluminescence signals.

 

Background-free Gamma and PET monitoring

 

The use of specific measuring cells simplifies the measurement of high activity PET isotopes even in high background laboratories.

A bulky and heavy lead shielding is not required as the system is insensitive to 511 keV gamma. Available cells include:

  • PET measuring cells
  • Luminescence measuring cells
  • Gamma measuring cells

 

Dual operation mode

 

The HERM system can be installed in multiple distinct configurations, providing more flexibility and convenience. The comfortable stand-alone configuration provides an analog signal which can be easily integrated into an existing HPLC system. The system is equipped with a flash memory and a powerful CPU. Alternatively, the system can be installed in the PC-controlled configuration via a USB connection for digital data acquisition.

 

Easy-to-use software for maximum productivity

 

The HERM Controller is the software interface to the instrument; it controls all functions and collects the data. The RadioStar software combines the ability to run sophisticated measurements with a user-friendly operation and user interface. In addition, a Chromeleon™ driver is available. Chromeleon™ is known as a very versatile chromatography software package supporting many different hardware solutions. The driver is fully certified and digitally signed by Thermo Scientific™ and runs with versions 6.x and 7.x.

 

Publications

 

Year Authors Journal Title
2021

Anton A. Larenkov, Artur G. Makichyan, and Vladimir N. Iatsenko

Molecules

Separation of 44Sc from 44Ti in the Context of A Generator System for Radiopharmaceutical Purposes with the Example of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T Synthesis

2020

Laurent Besret, Sébastien d’Heilly, Cathy Aubert, Guillaume Bluet, Florence Gruss-Leleu, Françoise Le-Gall, Anne Caron, Laurent Andrieu, Sylvie Vincent, Maysoun Shomali, Monsif Bouaboula, Carole Voland, Jeffrey Ming, Sébastien Roy, Srinivas Rao, Chantal Carrez,and Erwan Jouannot

EJNMMI Research

Translational strategy using multiple nuclear imaging biomarkers to evaluate target engagement and early therapeutic efficacy of SAR439859, a novel selective estrogen receptor degrader

2020

Anton Larenkov, Marat Rakhimov, Kristina Lunyova, Olga Klementyeva, Alesya Maruk and Aleksei Machulkin

Molecules

Pharmacokinetic Properties of 68Ga-labelled Folic Acid Conjugates: Improvement Using HEHE Tag

2019

Richard L. Hesketh, Jiazheng Wang, Alan J. Wright, David Y. Lewis, Alice E. Denton, Richard Grenfell, Jodi L. Miller, Robert Bielik, Marcel Gehrung, Maria Fala, Susana Ros, Bangwen Xie, De-en Hu, and Kevin M. Brindle

Cancer Research

Magnetic resonance imaging is more sensitive than PET for detecting treatment-induced cell death-dependent changes in glycolysis

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