Berthold HERM LB 500 with NaI detector

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Berthold HERM LB 500 with NaI detector

The HERM is a dedicated radio HPLC monitor which can be connected to different detectors providing flexibility, reproducibility and sensitivity. The HERM offers a safe and user-friendly solution for all quality control laboratories. The HERM with NaI detector for gamma and high energy beta isotopes combines an extremely sensitive NaI detector with compact shielding and can detect even low energy gamma isotopes like 125I with high efficiency. For PET and direct luminescence, the HERM with fLumo detector is available.

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Highlights

Simple integration into every HPLC system

The HERM makes integration into any existing HPLC system very easy. The PC connection can be established instantly via the USB port or by using the analog 0-1 V output. Its compact design makes it easy to fit in to a hot cell.

Sensitive and reliable measurement

The NaI detector option combines an extremely sensitive detector with a compact shielding. Even low energy gamma isotopes like ¹²⁵I can be detected with high efficiency. Lead shielding ensures low backgrounds even when there is high external radiation.

Easy operation and high flexibility

The HERM LB 500 has been designed to be intuitive and easy to use. This will get you up and running as quickly as possible. Standard tubing is used to create the flow cell volume and provides maximum flexibility. Changing cells is very easy because of the twin cell changer that enables the user to easily switch between two different cell volumes. If required by GLP regulations, the cell volume can be fixed to just one volume using the optional single volume insert. The system has been designed to avoid accidental parameter modifications eliminating manual adjustment as all instrument parameters are controlled remotely.

Dual operation mode

The HERM system can be installed in multiple distinct configurations, providing more flexibility and convenience. The comfortable stand-alone configuration provides an analog signal which can be easily integrated into an existing HPLC system. The system is equipped with a flash memory and a powerful CPU. Alternatively, the system can be installed in the PC-controlled configuration via a USB connection for digital data acquisition.

Easy-to-use software for maximum productivity

The HERM Controller is the software interface to the instrument; it controls all functions and collects the data. The RadioStar software combines the ability to run sophisticated measurements with a user-friendly interface. A Chromeleon™ driver is available, Chromeleon™ is known as a very versatile chromatography software package supporting many different hardware solutions. The driver is fully certified and digitally signed by Thermo Scientific™ and runs with versions 6.x and 7.x.

Applications

¹²⁵I quality control
Gamma metabolite studies (all gamma isotopes)

Publications

Year	Authors	Journal	Title
2022	Olga Ovdiichuk, Emilie Roeder, Sébastien Billotte, Nicolas Veran, and Charlotte Collet	Molecules	Fully Automated Macro- and Microfluidic Production of [68Ga]Ga-Citrate on mAIO® and iMiDEVTM Modules
2021	Felicia Krämer, Benedikt Gröner, Chris Hoffmann, Austin Craig, Melanie Brugger, Alexander Drzezga, Marco Timmer, Felix Neumaier, Boris D. Zlatopolskiy, Heike Endepols, and Bernd Neumaier	Cancers	Evaluation of 3-l- and 3-d-[¹⁸F]Fluorophenylalanines as PET Tracers for Tumor Imaging
2021	Albert Moussaron, Valérie Jouan-Hureaux, Charlotte Collet, Julien Pierson, Noémie Thomas, Laurence Choulier, Nicolas Veran, Matthieu Doyen, Philippe Arnoux, Fatiha Maskali, Dominique Dumas, Samir Acherar, Muriel Barberi-Heyob, and Céline Frochot	Molecules	Preliminary Study of New Gallium-68 Radiolabeled Peptide Targeting NRP-1 to Detect Brain Metastases by Positron Emission Tomography
2020	Boris D. Zlatopolskiy, Felix Neumaier, Till Rüngeler, Birte Drewes, Niklas Kolks and Bernd Neumaier	Molecules	Preparation of a First ¹⁸F-Labeled Agonist for M1 Muscarinic Acetylcholine Receptors
2020	Alexander Wurzer, Daniel Di Carlo, Alexander Schmidt, Roswitha Beck, Matthias Eiber, Markus Schwaiger and Hans-Jürgen Wester	Journal of Nuclear Medicine	Radiohybrid Ligands: A Novel Tracer Concept Exemplified by ¹⁸F- or ⁶⁸Ga-Labeled rhPSMA Inhibitors
2019	Kakali De, Dibyanti Mukherjee, Samarendu Sinha, and Shantanu Ganguly	EJNMMI Research	HYNIC and DOMA conjugated radiolabeled bombesin analogs as receptor-targeted probes for scintigraphic detection of breast tumor
2019	Julekha Kazi, Ria Mukhopadhyay, Ramkrishna Sen, Tarun Jha, Shantanu Ganguly and Mita Chatterjee Debnath	MedChemComm	Design of 5-fluorouracil (5-FU) loaded, folate conjugated peptide linked nanoparticles, a potential new drug carrier for selective targeting of tumor cells
2019	Dongjian Zhang, Meng Gao, Nan Yao, Cuihua Jiang, Wei Liu, Tiannv Li, Shaoli Song, Dejian Huang, Zhiqi Yin, Yunliang Qiu and Qiaomei Jin	Contrast Media and Molecular Imaging	Preclinical Evaluation of Radioiodinated Hoechst 33258 for Early Prediction of Tumor Response to Treatment of Vascular-Disrupting Agents

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General Enquiry: cs@medikonia.com | Support: support@medikonia.com

+852 2866 8995

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